Browsing by Author "Fitzgerald, Katherine A."
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Poxvirus protein N1L targets the I-kB kinase complex, inhibits signaling to NF-kB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kB and IRF3 signaling by toll-like receptors
Stack, Julianne; DiPerna, Gary; Bowie, Andrew G.; Boyd, Annemarie; Kotwal, Girish; Zhang, Zhouning; Arvikar, Sheila; Latz, Eicke; Fitzgerald, Katherine A.; Marshall, William L. (ASBMB [American Society for Biochemistry and Molecular Biology], 2004)Poxviruses encode proteins that suppress host immune responses, including secreted decoy receptors for pro-inflammatory cytokines such as interleukin-1 (IL-1) and the vaccinia virus proteins A46R and A52R that inhibit ... -
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
Stack, Julianne; Haga, Ismar R.; Schröder, Martina; Bartlett, Nathan W.; Maloney, Geraldine; Reading, Patrick C.; Fitzgerald, Katherine A.; Smith, Geoffrey L.; Bowie, Andrew G. (The Rockefeller University Press, 2005)Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ...